PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

28 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetSIRT6

E3Not specified

Cell lineSK-HEP-1

Detection targetprotein_degradation

Activity compounds and values

Activity records

28 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	=	11.9	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A013784	PGDB_C001486	PGDB_AS001403	View
% Degradation	-	=	66.2	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A013940	PGDB_C001518	PGDB_AS001403	View
% Degradation	-	=	81.2	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A014727	PGDB_C001520	PGDB_AS001403	View
% Degradation	-	=	68.3	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A015758	PGDB_C001499	PGDB_AS001403	View
% Degradation	-	=	85.9	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A016641	PGDB_C001489	PGDB_AS001403	View
% Degradation	-	=	49.3	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A017525	PGDB_C001503	PGDB_AS001403	View
% Degradation	-	=	89.4	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A027135	PGDB_C001510	PGDB_AS001403	View
% Degradation	-	=	64.3	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A027955	PGDB_C001522	PGDB_AS001403	View
% Degradation	-	=	67.7	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A030090	PGDB_C001506	PGDB_AS001403	View
% Degradation	-	=	84.9	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A033193	PGDB_C001492	PGDB_AS001403	View
% Degradation	-	=	35.6	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A034419	PGDB_C001496	PGDB_AS001403	View
% Degradation	-	=	60.5	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A037504	PGDB_C001519	PGDB_AS001403	View
% Degradation	-	=	69.6	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A038944	PGDB_C001516	PGDB_AS001403	View
% Degradation	-	=	78.3	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A039709	PGDB_C001494	PGDB_AS001403	View
% Degradation	-	=	46.1	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A043626	PGDB_C001517	PGDB_AS001403	View
% Degradation	-	=	53.2	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A043898	PGDB_C001504	PGDB_AS001403	View
% Degradation	-	=	94.5	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A046010	PGDB_C001488	PGDB_AS001403	View
% Degradation	-	<	10	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A050002	PGDB_C001487	PGDB_AS001403	View
% Degradation	-	<	10	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A054763	PGDB_C001508	PGDB_AS001403	View
% Degradation	-	=	58.7	%	200 nM	36 h	SIRT6	-	SK-HEP-1	CN119019370A	PGDB_A055436	PGDB_C001512	PGDB_AS001403	View

Rows per pagePage 1 of 2 · 28 recordsGo to page