PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(C(=O)O)cc1N(C(=O)C1C(C)(C)C1(C)C)c1ccc([N+](=O)[O-])c2nonc12

Compound summary

Compound IDPGDB_C007020

FormulaC22H22N4O6

Molecular weight438.44

InChIKeySCACPPNPOOSYNC-UHFFFAOYSA-N

Physicochemical properties

Exact mass438.1539

RDKit cLogP4.48

TPSA139.7

HBD / HBA1 / 7

Rotatable bonds5

Heavy atoms32

Hetero atoms10

Rings / aromatic4 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	2.832	uM	-	—	MYC	-	Daudi	CN120040371B	PGDB_A012175	PGDB_C007020	PGDB_AS000270	View
% Degradation	-	=	87.38	%	7.5 uM	24 h	MYC	-	Daudi	CN120040371B	PGDB_A019466	PGDB_C007020	PGDB_AS000814	View
% Degradation	-	=	95.1	%	12 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A022745	PGDB_C007020	PGDB_AS001763	View
IC50	-	=	6.833	uM	-	—	MYC	-	COLO 320DM	CN120040371B	PGDB_A029522	PGDB_C007020	PGDB_AS001884	View
% Degradation	-	=	89.28	%	7.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A030769	PGDB_C007020	PGDB_AS000998	View
% Degradation	-	=	35.19	%	3 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A032297	PGDB_C007020	PGDB_AS000007	View
IC50	-	=	0.921	uM	-	—	MYC	-	SJSA-1	CN120040371B	PGDB_A033541	PGDB_C007020	PGDB_AS000442	View
% Degradation	-	=	58.92	%	6 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A035975	PGDB_C007020	PGDB_AS002218	View
% Degradation	-	=	4.91	%	0.75 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A044276	PGDB_C007020	PGDB_AS000011	View
IC50	-	=	4.731	uM	-	—	MYC	-	MV-4-11	CN120040371B	PGDB_A045424	PGDB_C007020	PGDB_AS001813	View
% Degradation	-	=	79.15	%	7.5 uM	9 h	MYC	-	Daudi	CN120040371B	PGDB_A048655	PGDB_C007020	PGDB_AS000260	View
% Degradation	-	=	62.19	%	7.5 uM	3 h	MYC	-	Daudi	CN120040371B	PGDB_A052706	PGDB_C007020	PGDB_AS001136	View
% Degradation	-	=	12.93	%	1.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A054549	PGDB_C007020	PGDB_AS000827	View
IC50	-	=	8.832	uM	-	—	MYC	-	A2780	CN120040371B	PGDB_A068214	PGDB_C007020	PGDB_AS001017	View
% Degradation	-	=	76.92	%	7.5 uM	6 h	MYC	-	Daudi	CN120040371B	PGDB_A073522	PGDB_C007020	PGDB_AS002408	View

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