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SIMM · NJU
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SIMM · NJU
Patent
CN120040371B
80 compounds
485 activity records
15 assays
Patent summary
Publication number
CN120040371B
Assignee
Institute Of Medicinal Biotechnology Of Cams And Pumc
Title
A compound capable of targeted degradation of MYC and its applications
Family ID
95759037
Family members
2
Family patent IDs
CN120040371A
CN120040371B
Filing year
2025
Publication date
2026-01-27
Jurisdiction
CN
Compounds
80
Activity records
485
Assays
15
Activity compounds and values
Activity records
485 records
Structure
Metric
Control
Relation
Value
Unit
Concentration
Time
Target
E3
Cell line
Record ID
Compound
Assay
Details
IC50
-
=
0.863
uM
-
—
MYC
-
A2780
PGDB_A007074
PGDB_C007014
PGDB_AS001017
View
IC50
-
=
0.472
uM
-
—
MYC
-
Daudi
PGDB_A007203
PGDB_C007041
PGDB_AS000270
View
% Degradation
-
=
74.88
%
7.5 uM
9 h
MYC
-
Daudi
PGDB_A007457
PGDB_C007049
PGDB_AS000260
View
IC50
-
=
6.392
uM
-
—
MYC
-
SJSA-1
PGDB_A007470
PGDB_C006985
PGDB_AS000442
View
IC50
-
=
0.372
uM
-
—
MYC
-
Daudi
PGDB_A007671
PGDB_C007021
PGDB_AS000270
View
IC50
-
=
0.482
uM
-
—
MYC
-
MV-4-11
PGDB_A007826
PGDB_C006990
PGDB_AS001813
View
% Degradation
-
=
15.18
%
3 uM
12 h
MYC
-
Daudi
PGDB_A007915
PGDB_C007025
PGDB_AS000007
View
% Degradation
-
=
95.37
%
7.5 uM
12 h
MYC
-
Daudi
PGDB_A007944
PGDB_C007044
PGDB_AS000998
View
IC50
-
=
28.472
uM
-
—
MYC
-
MV-4-11
PGDB_A007947
PGDB_C007043
PGDB_AS001813
View
IC50
-
=
6.382
uM
-
—
MYC
-
MV-4-11
PGDB_A008207
PGDB_C007014
PGDB_AS001813
View
IC50
-
=
8.482
uM
-
—
MYC
-
COLO 320DM
PGDB_A008250
PGDB_C006996
PGDB_AS001884
View
IC50
-
=
8.612
uM
-
—
MYC
-
MV-4-11
PGDB_A008288
PGDB_C007040
PGDB_AS001813
View
IC50
-
=
6.382
uM
-
—
MYC
-
MV-4-11
PGDB_A008583
PGDB_C007062
PGDB_AS001813
View
IC50
-
=
5.382
uM
-
—
MYC
-
MV-4-11
PGDB_A008751
PGDB_C006999
PGDB_AS001813
View
IC50
-
=
0.954
uM
-
—
MYC
-
A2780
PGDB_A009065
PGDB_C007010
PGDB_AS001017
View
IC50
-
=
18.143
uM
-
—
MYC
-
SJSA-1
PGDB_A009471
PGDB_C006992
PGDB_AS000442
View
IC50
-
=
6.831
uM
-
—
MYC
-
MV-4-11
PGDB_A009694
PGDB_C007045
PGDB_AS001813
View
IC50
-
=
1.472
uM
-
—
MYC
-
MV-4-11
PGDB_A009827
PGDB_C007051
PGDB_AS001813
View
% Degradation
-
=
85.19
%
7.5 uM
12 h
MYC
-
Daudi
PGDB_A009832
PGDB_C007041
PGDB_AS000998
View
IC50
-
=
0.468
uM
-
—
MYC
-
Daudi
PGDB_A010060
PGDB_C007048
PGDB_AS000270
View
