PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)C(C(=O)N(c2cc(C(=O)O)ccc2C2CC2)c2ccc([N+](=O)[O-])c3nonc23)C1(C)C

Compound summary

Compound IDPGDB_C007041

FormulaC24H24N4O6

Molecular weight464.478

InChIKeyQRVMRXRPEIDEHG-UHFFFAOYSA-N

Physicochemical properties

Exact mass464.1696

RDKit cLogP5.05

TPSA139.7

HBD / HBA1 / 7

Rotatable bonds6

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 3

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.472	uM	-	—	MYC	-	Daudi	CN120040371B	PGDB_A007203	PGDB_C007041	PGDB_AS000270	View
% Degradation	-	=	85.19	%	7.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A009832	PGDB_C007041	PGDB_AS000998	View
% Degradation	-	=	1.47	%	7.5 uM	6 h	MYC	-	Daudi	CN120040371B	PGDB_A021635	PGDB_C007041	PGDB_AS002408	View
% Degradation	-	=	98.05	%	12 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A022019	PGDB_C007041	PGDB_AS001763	View
% Degradation	-	=	74.1	%	1.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A022275	PGDB_C007041	PGDB_AS000827	View
% Degradation	-	=	97.18	%	6 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A028945	PGDB_C007041	PGDB_AS002218	View
IC50	-	=	7.483	uM	-	—	MYC	-	COLO 320DM	CN120040371B	PGDB_A031799	PGDB_C007041	PGDB_AS001884	View
% Degradation	-	=	73.58	%	7.5 uM	9 h	MYC	-	Daudi	CN120040371B	PGDB_A038496	PGDB_C007041	PGDB_AS000260	View
% Degradation	-	=	0.58	%	7.5 uM	3 h	MYC	-	Daudi	CN120040371B	PGDB_A044974	PGDB_C007041	PGDB_AS001136	View
IC50	-	=	0.562	uM	-	—	MYC	-	MV-4-11	CN120040371B	PGDB_A056575	PGDB_C007041	PGDB_AS001813	View
IC50	-	=	7.832	uM	-	—	MYC	-	A2780	CN120040371B	PGDB_A061111	PGDB_C007041	PGDB_AS001017	View
% Degradation	-	=	92.18	%	7.5 uM	24 h	MYC	-	Daudi	CN120040371B	PGDB_A062743	PGDB_C007041	PGDB_AS000814	View
IC50	-	=	6.428	uM	-	—	MYC	-	SJSA-1	CN120040371B	PGDB_A063732	PGDB_C007041	PGDB_AS000442	View
% Degradation	-	=	48.94	%	0.75 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A069132	PGDB_C007041	PGDB_AS000011	View
% Degradation	-	=	96.99	%	3 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A071030	PGDB_C007041	PGDB_AS000007	View

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