PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CN1CCN(CC(=O)N(c2ccc(F)cc2C2CC2)c2ccc([N+](=O)[O-])c3nonc23)CC1

Compound summary

Compound IDPGDB_C007044

FormulaC22H23FN6O4

Molecular weight454.462

InChIKeyFDGHQOSYRWFNIC-UHFFFAOYSA-N

Physicochemical properties

Exact mass454.1765

RDKit cLogP3.06

TPSA108.8

HBD / HBA0 / 8

Rotatable bonds6

Heavy atoms33

Hetero atoms11

Rings / aromatic5 / 3

Fraction Csp30.41

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	95.37	%	7.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A007944	PGDB_C007044	PGDB_AS000998	View
% Degradation	-	=	78.19	%	7.5 uM	3 h	MYC	-	Daudi	CN120040371B	PGDB_A015964	PGDB_C007044	PGDB_AS001136	View
% Degradation	-	=	96.38	%	12 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A017979	PGDB_C007044	PGDB_AS001763	View
IC50	-	=	0.856	uM	-	—	MYC	-	SJSA-1	CN120040371B	PGDB_A018629	PGDB_C007044	PGDB_AS000442	View
% Degradation	-	=	62.47	%	3 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A019580	PGDB_C007044	PGDB_AS000007	View
IC50	-	=	0.842	uM	-	—	MYC	-	COLO 320DM	CN120040371B	PGDB_A025039	PGDB_C007044	PGDB_AS001884	View
IC50	-	=	0.473	uM	-	—	MYC	-	A2780	CN120040371B	PGDB_A025192	PGDB_C007044	PGDB_AS001017	View
IC50	-	=	0.842	uM	-	—	MYC	-	MV-4-11	CN120040371B	PGDB_A051908	PGDB_C007044	PGDB_AS001813	View
% Degradation	-	=	23.17	%	1.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A053264	PGDB_C007044	PGDB_AS000827	View
% Degradation	-	=	88.28	%	7.5 uM	6 h	MYC	-	Daudi	CN120040371B	PGDB_A055051	PGDB_C007044	PGDB_AS002408	View
% Degradation	-	=	92.48	%	7.5 uM	9 h	MYC	-	Daudi	CN120040371B	PGDB_A057265	PGDB_C007044	PGDB_AS000260	View
% Degradation	-	=	98.26	%	7.5 uM	24 h	MYC	-	Daudi	CN120040371B	PGDB_A060419	PGDB_C007044	PGDB_AS000814	View
% Degradation	-	=	88.47	%	6 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A070103	PGDB_C007044	PGDB_AS002218	View
% Degradation	-	=	9.27	%	0.75 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A074632	PGDB_C007044	PGDB_AS000011	View
IC50	-	=	0.026	uM	-	—	MYC	-	Daudi	CN120040371B	PGDB_A077288	PGDB_C007044	PGDB_AS000270	View

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