PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc(C(=O)N(c2ccc(F)cc2C2CC2)c2ccc([N+](=O)[O-])c3nonc23)cc(O)n1

Compound summary

Compound IDPGDB_C007063

FormulaC22H16FN5O5

Molecular weight449.398

InChIKeyDGUUVKCTRXAHIA-UHFFFAOYSA-N

Physicochemical properties

Exact mass449.1135

RDKit cLogP4.54

TPSA135.5

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms33

Hetero atoms11

Rings / aromatic5 / 4

Fraction Csp30.18

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	97.19	%	7.5 uM	24 h	MYC	-	Daudi	CN120040371B	PGDB_A014316	PGDB_C007063	PGDB_AS000814	View
% Degradation	-	=	91.29	%	12 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A018700	PGDB_C007063	PGDB_AS001763	View
% Degradation	-	=	65.28	%	7.5 uM	6 h	MYC	-	Daudi	CN120040371B	PGDB_A020788	PGDB_C007063	PGDB_AS002408	View
% Degradation	-	=	61.23	%	1.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A022085	PGDB_C007063	PGDB_AS000827	View
IC50	-	=	9.392	uM	-	—	MYC	-	Daudi	CN120040371B	PGDB_A025868	PGDB_C007063	PGDB_AS000270	View
% Degradation	-	=	89.19	%	6 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A028840	PGDB_C007063	PGDB_AS002218	View
% Degradation	-	=	44.27	%	7.5 uM	3 h	MYC	-	Daudi	CN120040371B	PGDB_A029919	PGDB_C007063	PGDB_AS001136	View
IC50	-	=	8.437	uM	-	—	MYC	-	COLO 320DM	CN120040371B	PGDB_A047038	PGDB_C007063	PGDB_AS001884	View
IC50	-	=	2.472	uM	-	—	MYC	-	SJSA-1	CN120040371B	PGDB_A051956	PGDB_C007063	PGDB_AS000442	View
% Degradation	-	=	81.29	%	7.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A059940	PGDB_C007063	PGDB_AS000998	View
IC50	-	=	2.483	uM	-	—	MYC	-	A2780	CN120040371B	PGDB_A063148	PGDB_C007063	PGDB_AS001017	View
% Degradation	-	=	72.11	%	7.5 uM	9 h	MYC	-	Daudi	CN120040371B	PGDB_A069637	PGDB_C007063	PGDB_AS000260	View
IC50	-	=	7.382	uM	-	—	MYC	-	MV-4-11	CN120040371B	PGDB_A070933	PGDB_C007063	PGDB_AS001813	View
% Degradation	-	=	81.1	%	3 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A072003	PGDB_C007063	PGDB_AS000007	View
% Degradation	-	=	43.9	%	0.75 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A077766	PGDB_C007063	PGDB_AS000011	View

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