PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1nc(-c2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)ccc1CN1CC(C2CCC(F)(F)CC2)C1

Compound summary

Compound IDPGDB_C008148

FormulaC28H30F3N5O3

Molecular weight541.574

InChIKeyWFRMFYGYKOBRFI-UHFFFAOYSA-N

Physicochemical properties

Exact mass541.2301

RDKit cLogP3.49

TPSA108.6

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms39

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.5

Formal charge0

Fragments1

Activity compounds and values

Activity records

22 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	90.9	nM	-	—	IKZF1	-	Jurkat	CN121646585A	PGDB_A015191	PGDB_C008148	PGDB_AS002085	View
DC50	-	=	4.4	nM	-	—	IKZF2	-	Jurkat	CN121646585A	PGDB_A015654	PGDB_C008148	PGDB_AS000135	View
% Degradation	-	=	81-86	%	-	13 d	IKZF2	-	-	CN121646585A	PGDB_A017506	PGDB_C008148	PGDB_AS002300	View
% Degradation	-	=	80-84	%	Concentration context: titrated doses	24 h	IKZF3	-	-	CN121646585A	PGDB_A022416	PGDB_C008148	PGDB_AS002342	View
DC50	-	=	0.1	nM	-	—	IKZF2	-	-	CN121646585A	PGDB_A023961	PGDB_C008148	PGDB_AS001421	View
% Degradation	-	=	71-72	%	Concentration context: titrated doses	13 d	IKZF4	-	-	CN121646585A	PGDB_A026871	PGDB_C008148	PGDB_AS001233	View
% Degradation	-	=	86	%	Concentration context: titrated doses	24 h	IKZF1	-	-	CN121646585A	PGDB_A027024	PGDB_C008148	PGDB_AS002210	View
DC50	-	=	33-36	nM	-	—	IKZF3	-	-	CN121646585A	PGDB_A030303	PGDB_C008148	PGDB_AS001088	View
DC50	-	=	1.3-1.6	nM	-	—	IKZF4	-	-	CN121646585A	PGDB_A030503	PGDB_C008148	PGDB_AS000563	View
Dmax	-	=	71-72	%	-	13 d	IKZF4	-	-	CN121646585A	PGDB_A033285	PGDB_C008148	PGDB_AS000779	View
Dmax	-	=	48	%	-	72 h	IKZF3	-	Jurkat	CN121646585A	PGDB_A036520	PGDB_C008148	PGDB_AS000276	View
Dmax	-	=	69	%	-	72 h	IKZF1	-	Jurkat	CN121646585A	PGDB_A044722	PGDB_C008148	PGDB_AS000236	View
DC50	-	=	194	nM	-	—	IKZF1	-	-	CN121646585A	PGDB_A050781	PGDB_C008148	PGDB_AS001153	View
Dmax	-	=	92	%	-	72 h	IKZF2	-	Jurkat	CN121646585A	PGDB_A054610	PGDB_C008148	PGDB_AS000940	View
Dmax	-	=	62	%	-	20 h	IKZF1	-	-	CN121646585A	PGDB_A057358	PGDB_C008148	PGDB_AS002159	View
Dmax	-	=	86	%	-	24 h	IKZF1	-	-	CN121646585A	PGDB_A064806	PGDB_C008148	PGDB_AS000956	View
DC50	-	=	36-172	nM	-	—	IKZF2	-	-	CN121646585A	PGDB_A068713	PGDB_C008148	PGDB_AS001453	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	CN121646585A	PGDB_A070809	PGDB_C008148	PGDB_AS001077	View
Dmax	-	=	96	%	-	20 h	IKZF2	-	-	CN121646585A	PGDB_A072072	PGDB_C008148	PGDB_AS001073	View
DC50	-	=	35-44	nM	-	—	IKZF1	-	-	CN121646585A	PGDB_A074939	PGDB_C008148	PGDB_AS001672	View

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