PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN121646585A

AssigneeBristol Myers Squibb

TitleSubstituted oxo-isoindolinyl piperidine-2, 6-dione compounds as anticancer agents

Family ID91953739

Family members5

Filing year2024

Publication date2026-03-10

JurisdictionCN

Compounds3

Activity records63

Assays22

Activity compounds and values

Activity records

63 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	39	%	Concentration context: titrated doses	24 h	IKZF3	-	-	PGDB_A011804	PGDB_C007381	PGDB_AS001615	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	PGDB_A012059	PGDB_C007382	PGDB_AS000563	View
DC50	-	=	2.9	nM	-	—	IKZF2	-	Jurkat	PGDB_A012401	PGDB_C007381	PGDB_AS000135	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	PGDB_A013040	PGDB_C007381	PGDB_AS001672	View
DC50	-	=	0.1	nM	-	—	IKZF4	-	-	PGDB_A013101	PGDB_C007381	PGDB_AS000563	View
DC50	-	=	90.9	nM	-	—	IKZF1	-	Jurkat	PGDB_A015191	PGDB_C008148	PGDB_AS002085	View
DC50	-	=	4.4	nM	-	—	IKZF2	-	Jurkat	PGDB_A015654	PGDB_C008148	PGDB_AS000135	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	PGDB_A016332	PGDB_C007381	PGDB_AS001077	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	PGDB_A017032	PGDB_C007381	PGDB_AS002085	View
% Degradation	-	=	81-86	%	-	13 d	IKZF2	-	-	PGDB_A017506	PGDB_C008148	PGDB_AS002300	View
DC50	-	=	11	nM	-	—	IKZF2	-	-	PGDB_A017673	PGDB_C007382	PGDB_AS001421	View
Dmax	-	=	2	%	Concentration context: titrated doses	24 h	IKZF3	-	-	PGDB_A019376	PGDB_C007382	PGDB_AS001615	View
DC50	-	=	2.2	nM	-	—	IKZF2	-	-	PGDB_A021302	PGDB_C007381	PGDB_AS001453	View
Dmax	-	=	48	%	-	72 h	IKZF1	-	Jurkat	PGDB_A022353	PGDB_C007382	PGDB_AS000236	View
% Degradation	-	=	80-84	%	Concentration context: titrated doses	24 h	IKZF3	-	-	PGDB_A022416	PGDB_C008148	PGDB_AS002342	View
DC50	-	>	10000	nM	-	—	IKZF1	-	-	PGDB_A023263	PGDB_C007381	PGDB_AS001153	View
DC50	-	=	0.1	nM	-	—	IKZF2	-	-	PGDB_A023961	PGDB_C008148	PGDB_AS001421	View
% Degradation	-	=	71-72	%	Concentration context: titrated doses	13 d	IKZF4	-	-	PGDB_A026871	PGDB_C008148	PGDB_AS001233	View
% Degradation	-	=	86	%	Concentration context: titrated doses	24 h	IKZF1	-	-	PGDB_A027024	PGDB_C008148	PGDB_AS002210	View
Dmax	-	=	92	%	-	13 d	IKZF4	-	-	PGDB_A028676	PGDB_C007381	PGDB_AS000779	View

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