PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN118234721A

AssigneeKorea Research Institute Of Chemical Technology Krict

TitleGlutarimide moiety based isoindolinone derivatives and use thereof

Family ID91498194

Family members1

Filing year2022

Publication date2024-06-14

JurisdictionCN

Compounds71

Activity records96

Assays5

Activity compounds and values

Activity records

96 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Cell viability	-	=	18.59	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A008426	PGDB_C019860	PGDB_AS001755	View
IC50	-	=	10-50	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A008864	PGDB_C019819	PGDB_AS001194	View
% Cell viability	-	=	5.94	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A009820	PGDB_C019837	PGDB_AS002076	View
IC50	-	=	0.0001-0.01	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A010265	PGDB_C019806	PGDB_AS001194	View
IC50	-	=	0.0001-0.01	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A010403	PGDB_C019805	PGDB_AS001194	View
% Cell viability	-	=	16.25	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A011752	PGDB_C019856	PGDB_AS001120	View
IC50	-	=	0.0001-0.01	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A011958	PGDB_C019794	PGDB_AS001194	View
IC50	-	=	0.01-1	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A012460	PGDB_C019818	PGDB_AS001194	View
IC50	-	=	0.0001-0.01	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A012582	PGDB_C019803	PGDB_AS001194	View
% Cell viability	-	=	102.33	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A012811	PGDB_C019840	PGDB_AS001589	View
% Cell viability	-	=	26.15	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A013746	PGDB_C019846	PGDB_AS001120	View
% Cell viability	-	=	33.03	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A014405	PGDB_C019849	PGDB_AS001120	View
% Cell viability	-	=	15.2	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A016310	PGDB_C019856	PGDB_AS001755	View
% Cell viability	-	=	26.41	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A016972	PGDB_C019847	PGDB_AS001755	View
% Cell viability	-	=	83.78	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A017442	PGDB_C019838	PGDB_AS001589	View
% Cell viability	-	=	28.02	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A017767	PGDB_C019853	PGDB_AS001120	View
% Cell viability	-	=	24.44	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A017913	PGDB_C019848	PGDB_AS001755	View
% Cell viability	-	=	32.13	%	10 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A018244	PGDB_C019852	PGDB_AS001120	View
% Cell viability	-	=	24.38	%	500 nM	72 h	GSPT1	CRBN	NCI-H1155	PGDB_A022013	PGDB_C019846	PGDB_AS001755	View
IC50	-	=	0.0001-0.01	uM	-	—	GSPT1	CRBN	KG-1	PGDB_A023826	PGDB_C019811	PGDB_AS001194	View

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