PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberKR20210031923A

AssigneeNovartis

Title3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of IKAROS family zinc finger 2 (IKZF2) dependent diseases

Family ID68136442

Family members25

Filing year2019

Publication date2021-03-23

JurisdictionKR

Compounds28

Activity records97

Assays4

Activity compounds and values

Activity records

97 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	70	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A007101	PGDB_C008953	PGDB_AS000273	View
EC50	-	>	50	uM	-	—	GSPT1	-	293GT	PGDB_A007792	PGDB_C008951	PGDB_AS000422	View
% Degradation	-	=	30	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A009660	PGDB_C008942	PGDB_AS000273	View
% Degradation	-	=	65	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A011112	PGDB_C008949	PGDB_AS000273	View
% Degradation	-	=	65	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A012075	PGDB_C008940	PGDB_AS000273	View
EC50	-	=	0.029	uM	-	—	IKZF2	-	293GT	PGDB_A014227	PGDB_C008712	PGDB_AS002503	View
EC50	-	=	0.051	uM	-	—	IKZF1	-	293GT	PGDB_A014323	PGDB_C008952	PGDB_AS001106	View
EC50	-	>	50	uM	-	—	IKZF1	-	293GT	PGDB_A014915	PGDB_C008940	PGDB_AS001106	View
EC50	-	=	0.066	uM	-	—	IKZF2	-	293GT	PGDB_A015188	PGDB_C008958	PGDB_AS002503	View
EC50	-	=	0.57	uM	-	—	IKZF1	-	293GT	PGDB_A015973	PGDB_C008958	PGDB_AS001106	View
% Degradation	-	=	10	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A016548	PGDB_C008945	PGDB_AS000273	View
EC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A017362	PGDB_C008948	PGDB_AS001106	View
EC50	-	>	50	uM	-	—	GSPT1	-	293GT	PGDB_A018097	PGDB_C008953	PGDB_AS000422	View
EC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A018307	PGDB_C008955	PGDB_AS001106	View
EC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A018851	PGDB_C008963	PGDB_AS001106	View
EC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A019090	PGDB_C008960	PGDB_AS001106	View
EC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A019126	PGDB_C008953	PGDB_AS001106	View
EC50	-	>	50	uM	-	—	IKZF1	-	293GT	PGDB_A021266	PGDB_C008941	PGDB_AS001106	View
EC50	-	=	0.049	uM	-	—	IKZF2	-	293GT	PGDB_A021323	PGDB_C008952	PGDB_AS002503	View
% Degradation	-	=	65	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A021405	PGDB_C008940	PGDB_AS000273	View

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