PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2023244806A1

AssigneePlexium

TitleCompounds and pharmaceutical compositions that degrade swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a

Family ID87312202

Family members5

Filing year2023

Publication date2023-12-21

JurisdictionWO

Compounds427

Activity records1,692

Assays4

Activity compounds and values

Activity records

1,692 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007069	PGDB_C027032	PGDB_AS000849	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007103	PGDB_C027234	PGDB_AS000849	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007104	PGDB_C026990	PGDB_AS002237	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007120	PGDB_C026916	PGDB_AS000849	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007167	PGDB_C027074	PGDB_AS001988	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007201	PGDB_C027300	PGDB_AS000849	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007253	PGDB_C027236	PGDB_AS000073	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007303	PGDB_C027007	PGDB_AS000073	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007331	PGDB_C027214	PGDB_AS002237	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007332	PGDB_C027190	PGDB_AS000073	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007334	PGDB_C027072	PGDB_AS000073	View
DC50	-	<	0.05	uM	-	—	SMARCA4	-	HeLa	PGDB_A007367	PGDB_C026903	PGDB_AS000073	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007444	PGDB_C026883	PGDB_AS001988	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007459	PGDB_C026977	PGDB_AS001988	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007500	PGDB_C027086	PGDB_AS000073	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007530	PGDB_C027169	PGDB_AS002237	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007531	PGDB_C027257	PGDB_AS002237	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007604	PGDB_C027026	PGDB_AS000073	View
DC50	-	=	0.05-0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007635	PGDB_C027053	PGDB_AS002237	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007694	PGDB_C027037	PGDB_AS000849	View

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