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SIMM · NJU
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SIMM · NJU
Patent
WO2025181261A1
137 compounds
278 activity records
4 assays
Patent summary
Publication number
WO2025181261A1
Assignee
Monte Rosa Therapeutics
Title
Cyclopropyl and 1,3,4-oxodiazole compounds that mediate protein degradation and methods of use thereof
Family ID
90123818
Family members
2
Family patent IDs
WO2025181261A1
WO2025181261A9
Filing year
2025
Publication date
2025-09-04
Jurisdiction
WO
Compounds
137
Activity records
278
Assays
4
Activity compounds and values
Activity records
278 records
Structure
Metric
Control
Relation
Value
Unit
Concentration
Time
Target
E3
Cell line
Record ID
Compound
Assay
Details
Dmax
-
=
6
%
-
-
GSPT1
-
HEK293
PGDB_A007211
PGDB_C011282
PGDB_AS001674
View
Dmax
-
=
45.6
%
-
-
CDK2
-
HEK293
PGDB_A007262
PGDB_C011348
PGDB_AS000913
View
Dmax
-
=
56.6
%
-
-
CDK2
-
HEK293
PGDB_A007268
PGDB_C011366
PGDB_AS000913
View
Dmax
-
=
7.5
%
-
-
GSPT1
-
HEK293
PGDB_A007583
PGDB_C011364
PGDB_AS001674
View
Dmax
-
=
52.6
%
-
-
CDK2
-
HEK293
PGDB_A007710
PGDB_C011363
PGDB_AS000913
View
Dmax
-
=
52
%
-
-
CDK2
-
HEK293
PGDB_A007921
PGDB_C011290
PGDB_AS000913
View
Dmax
-
=
47.7
%
-
-
CDK2
-
HEK293
PGDB_A007945
PGDB_C011292
PGDB_AS000913
View
Dmax
-
=
2.9
%
-
-
GSPT1
-
HEK293
PGDB_A007946
PGDB_C011339
PGDB_AS001674
View
Dmax
-
=
52.3
%
-
-
CDK2
-
HEK293
PGDB_A008883
PGDB_C011399
PGDB_AS000913
View
Dmax
-
=
41.6
%
-
-
CDK2
-
HEK293
PGDB_A009336
PGDB_C011396
PGDB_AS000913
View
Dmax
-
=
56.4
%
-
-
CDK2
-
HEK293
PGDB_A009401
PGDB_C011316
PGDB_AS000913
View
Dmax
-
=
40.6
%
-
-
CDK2
-
HEK293
PGDB_A009415
PGDB_C011322
PGDB_AS000913
View
Dmax
-
=
2.6
%
-
-
GSPT1
-
HEK293
PGDB_A009498
PGDB_C011371
PGDB_AS001674
View
Dmax
-
=
5.1
%
-
-
GSPT1
-
HEK293
PGDB_A009631
PGDB_C011288
PGDB_AS001674
View
Dmax
-
=
14.6
%
-
-
GSPT1
-
HEK293
PGDB_A010014
PGDB_C011314
PGDB_AS001674
View
Dmax
-
=
6.9
%
-
-
GSPT1
-
HEK293
PGDB_A010729
PGDB_C011349
PGDB_AS001674
View
Dmax
-
=
46.3
%
-
-
CDK2
-
HEK293
PGDB_A011192
PGDB_C011319
PGDB_AS000913
View
Dmax
-
=
55.8
%
-
-
CDK2
-
HEK293
PGDB_A011782
PGDB_C011390
PGDB_AS000913
View
Dmax
-
=
12.1
%
-
-
GSPT1
-
HEK293
PGDB_A012037
PGDB_C011309
PGDB_AS001674
View
Dmax
-
=
51.4
%
-
-
CDK2
-
HEK293
PGDB_A012314
PGDB_C011297
PGDB_AS000913
View
