Activity record

PGDB_A008513

Assay: % DegradationTarget: IKZF1QC: ambiguous
Activity overview

DC50 = 0.077 nM

TargetIKZF1
Cell lineNCI-H929
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS002338
PatentCA3286762A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025617
Compound IDPGDB_C025617
CompoundExample 23
Source record IDPGDB_C006130
InChIKeyDMUCIXLYLXFAGV-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002338
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929

Source evidence

Patent IDCA3286762A1
Compound location

Example 23

Example 23 enlarged structureExample 23 location on patent page 74
Activity table
Page 102 · table single