PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ncn(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)n1

Compound summary

Compound IDPGDB_C025617

FormulaC36H34N8O3

Molecular weight626.721

InChIKeyDMUCIXLYLXFAGV-UHFFFAOYSA-N

Physicochemical properties

Exact mass626.2754

RDKit cLogP3.8

TPSA116.6

HBD / HBA1 / 9

Rotatable bonds7

Heavy atoms47

Hetero atoms11

Rings / aromatic8 / 5

Fraction Csp30.28

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	0.077	nM	-	—	IKZF1	-	NCI-H929	CA3286762A1	PGDB_A008513	PGDB_C025617	PGDB_AS002338	View
Dmax	-	=	77.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF3	-	NCI-H929	CA3286762A1	PGDB_A009731	PGDB_C025617	PGDB_AS001097	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A015343	PGDB_C025617	PGDB_AS001501	View
IC50	-	=	19	nM	-	—	-	-	-	EP4685141A1	PGDB_A027498	PGDB_C025617	PGDB_AS001840	View
IC50	-	=	19	nM	-	—	-	-	-	EP4685141A1	PGDB_A040011	PGDB_C025617	PGDB_AS001083	View
IC50	-	=	19	nM	-	—	-	-	-	EP4685141A1	PGDB_A044737	PGDB_C025617	PGDB_AS000581	View
Dmax	-	=	65.8	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF1	-	NCI-H929	CA3286762A1	PGDB_A047362	PGDB_C025617	PGDB_AS000833	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	CA3286762A1	PGDB_A050053	PGDB_C025617	PGDB_AS001402	View
IC50	-	=	19	nM	-	—	-	-	-	EP4685141A1	PGDB_A050086	PGDB_C025617	PGDB_AS001275	View
DC50	-	=	0.077	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A051678	PGDB_C025617	PGDB_AS001024	View
DC50	-	=	0.036	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A056641	PGDB_C025617	PGDB_AS000575	View
Dmax	-	=	65.8	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	-	-	NCI-H929	EP4685141A1	PGDB_A060861	PGDB_C025617	PGDB_AS000327	View
Dmax	-	=	77.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	-	-	NCI-H929	EP4685141A1	PGDB_A070308	PGDB_C025617	PGDB_AS002256	View
DC50	-	=	0.036	nM	-	—	IKZF3	-	NCI-H929	CA3286762A1	PGDB_A070716	PGDB_C025617	PGDB_AS000521	View
IC50	-	=	19	nM	-	—	CRBN	CRBN	-	CA3286762A1	PGDB_A075271	PGDB_C025617	PGDB_AS001113	View

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