Activity record

PGDB_A017018

Assay: % DegradationTarget: IKZF1QC: ambiguous
Activity overview

Dmax = 57.1 %

TargetIKZF1
Cell lineNCI-H929
ConcentrationConcentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM
Time24 h
Assay / ReadoutDmax / % Degradation
Assay IDPGDB_AS000833
PatentCA3286762A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025615
Compound IDPGDB_C025615
CompoundExample 21
Source record IDPGDB_C006117
InChIKeyMDWDRPAHWBVXTM-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000833
Assay family% Degradation
Assay systemcell_based
ReadoutDmax
ConcentrationConcentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929

Source evidence

Patent IDCA3286762A1
Compound location

Example 21

Example 21 enlarged structureExample 21 location on patent page 73
Activity table
Page 102 · table single