PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ncc(-c2nc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)cc(C(F)(F)F)n2)s1

Compound summary

Compound IDPGDB_C025615

FormulaC37H32F3N7O3S

Molecular weight711.77

InChIKeyMDWDRPAHWBVXTM-UHFFFAOYSA-N

Physicochemical properties

Exact mass711.2239

RDKit cLogP5.76

TPSA111.6

HBD / HBA1 / 9

Rotatable bonds7

Heavy atoms51

Hetero atoms14

Rings / aromatic8 / 5

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	74.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	-	-	NCI-H929	EP4685141A1	PGDB_A014693	PGDB_C025615	PGDB_AS002256	View
IC50	-	=	34	nM	-	—	-	-	-	EP4685141A1	PGDB_A016448	PGDB_C025615	PGDB_AS001275	View
Dmax	-	=	57.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF1	-	NCI-H929	CA3286762A1	PGDB_A017018	PGDB_C025615	PGDB_AS000833	View
DC50	-	=	0.22	nM	-	—	IKZF3	-	NCI-H929	CA3286762A1	PGDB_A017797	PGDB_C025615	PGDB_AS000521	View
IC50	-	=	0.2	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A023552	PGDB_C025615	PGDB_AS001501	View
IC50	-	=	34	nM	-	—	-	-	-	EP4685141A1	PGDB_A026101	PGDB_C025615	PGDB_AS001083	View
DC50	-	=	0.22	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A026595	PGDB_C025615	PGDB_AS000575	View
IC50	-	=	34	nM	-	—	-	-	-	EP4685141A1	PGDB_A029526	PGDB_C025615	PGDB_AS000581	View
DC50	-	=	8.86	nM	-	—	IKZF1	-	NCI-H929	CA3286762A1	PGDB_A046563	PGDB_C025615	PGDB_AS002338	View
Dmax	-	=	74.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF3	-	NCI-H929	CA3286762A1	PGDB_A058978	PGDB_C025615	PGDB_AS001097	View
IC50	-	=	0.2	nM	-	—	-	-	NCI-H929	CA3286762A1	PGDB_A067446	PGDB_C025615	PGDB_AS001402	View
IC50	-	=	34	nM	-	—	-	-	-	EP4685141A1	PGDB_A070386	PGDB_C025615	PGDB_AS001840	View
DC50	-	=	8.86	nM	-	—	-	-	NCI-H929	EP4685141A1	PGDB_A074731	PGDB_C025615	PGDB_AS001024	View
Dmax	-	=	57.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	-	-	NCI-H929	EP4685141A1	PGDB_A074876	PGDB_C025615	PGDB_AS000327	View
IC50	-	=	34	nM	-	—	CRBN	CRBN	-	CA3286762A1	PGDB_A075299	PGDB_C025615	PGDB_AS001113	View

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