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SIMM · NJU

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A patent-derived molecular glue bioactivity database with traceable evidence.

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SIMM · NJU

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SIMM · NJU

Activity record

PGDB_A021524

Assay: % DegradationTarget: GSPT1QC: standardized

Activity overview

Dmax = 88.3 %

TargetGSPT1

Cell lineHEK293

ConcentrationConcentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM

Time72 h

Assay / Readoutluminescence / Dmax

Assay IDPGDB_AS002464

PatentIL323841A

QC statusstandardized

Evidence details

Compound, assay context, and source

Compound

Compound IDPGDB_C008165

Compound14

Source record IDPGDB_C008165

InChIKeyXCPKJDRATSDOEN-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002464

Assay family% Degradation

Assay systemcell_based

ReadoutDmax

Technologyluminescence

ConcentrationConcentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM

Treatment time72 h

Detection targetprotein_degradation

TargetGSPT1

E3Not specified

Cell lineHEK293

OrganismHomo sapiens

Source evidence

Patent IDIL323841A

Compound location

14

14 enlarged structure

14 location on patent page 53

Activity table

Page 59 · table start

Page 60 · table end

A patent-derived molecular glue bioactivity database with traceable evidence.

Global reach

0

0 countries/regions

·

SIMM · NJU