PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberIL323841A

AssigneeCyrus Therapeutics, Dong Hyuk Ki, Jaeyung Lee, Joonwoo Nam, Kim Eun Jung, Min Sung Joo, Wooseok Han

TitleNew GSPT1 Joint and Its Use

Family ID87802229

Family members11

Filing year2025

Publication date2025-12-01

JurisdictionIL

Compounds22

Activity records177

Assays16

Activity compounds and values

Activity records

177 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	=	253	nM	-	—	GSPT1	-	HEK293	PGDB_A007222	PGDB_C008163	PGDB_AS002492	View
IC50	-	=	1850	nM	-	—	GSPT1	-	MOLM-13	PGDB_A007247	PGDB_C001361	PGDB_AS000128	View
IC50	-	=	18.6	nM	-	—	GSPT1	-	MV-4-11	PGDB_A007423	PGDB_C008150	PGDB_AS001937	View
IC50	-	=	61.4	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A007532	PGDB_C008162	PGDB_AS000925	View
EC50	-	=	68.4	nM	-	—	GSPT1	-	HEK293	PGDB_A008332	PGDB_C008166	PGDB_AS002492	View
IC50	-	=	57.1	nM	-	—	GSPT1	-	HL-60	PGDB_A009008	PGDB_C008149	PGDB_AS000799	View
IC50	-	=	31.3	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A010285	PGDB_C008151	PGDB_AS002011	View
Kd	-	=	7.3	nM	-	—	CRBN	CRBN	HEK293	PGDB_A010767	PGDB_C008152	PGDB_AS001216	View
EC50	-	=	153	nM	-	—	GSPT1	-	HEK293	PGDB_A011074	PGDB_C008164	PGDB_AS002492	View
IC50	-	=	33.6	nM	-	—	GSPT1	-	HL-60	PGDB_A011134	PGDB_C008152	PGDB_AS000799	View
IC50	-	=	396	nM	-	—	GSPT1	-	MOLM-13	PGDB_A011359	PGDB_C008150	PGDB_AS002158	View
IC50	-	=	57.1	nM	-	—	GSPT1	-	HL-60	PGDB_A011447	PGDB_C008150	PGDB_AS002473	View
EC50	-	=	198.3	nM	-	—	GSPT1	-	HEK293	PGDB_A012632	PGDB_C001361	PGDB_AS002492	View
DC50	-	>	10000	nM	-	—	GSPT1	-	HEK293	PGDB_A013017	PGDB_C019545	PGDB_AS000381	View
Dmax	-	=	18	%	Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM	72 h	GSPT1	-	HEK293	PGDB_A013652	PGDB_C008158	PGDB_AS002464	View
EC50	-	=	144.9	nM	-	—	GSPT1	-	HEK293	PGDB_A013905	PGDB_C008162	PGDB_AS002492	View
IC50	-	=	68.2	nM	-	—	GSPT1	-	HL-60	PGDB_A014388	PGDB_C008162	PGDB_AS002473	View
Dmax	-	=	88.6	%	Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM	72 h	GSPT1	-	HEK293	PGDB_A014822	PGDB_C008153	PGDB_AS002464	View
IC50	-	=	99.8	nM	-	—	GSPT1	-	HL-60	PGDB_A015068	PGDB_C001361	PGDB_AS000799	View
Dmax	-	=	76.5	%	Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM	72 h	GSPT1	-	HEK293	PGDB_A015153	PGDB_C008164	PGDB_AS002464	View

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