Activity record

PGDB_A027361

Assay: bindingTarget: CRBNQC: ambiguous
Activity overview

IC50 = 57 nM

TargetCRBN
E3 ligaseCRBN
Cell lineNCI-H1155
Time3 d
Assay / Readoutluminescence / IC50
Assay IDPGDB_AS001968
PatentWO2024125437A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C000378
Compound IDPGDB_C000378
Compound化合物 B
Source record IDPGDB_C000378
InChIKeyRCXVTRGVNASBGN-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001968
Assay familybinding
Assay systemcell_based
ReadoutIC50
Technologyluminescence
Treatment time3 d
TargetCRBN
E3CRBN
Cell lineNCI-H1155
OrganismHomo sapiens

Source evidence

Patent IDWO2024125437A1
Compound location

化合物 B

化合物 B enlarged structure化合物 B location on patent page 35
Activity table
Page 37 · table single