PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024125437A1

AssigneeNanjing Sanhome Pharmaceutical

TitleGspt1 degradation agent and use thereof

Family ID91400672

Family members2

Filing year2023

Publication date2024-06-20

JurisdictionWO

Compounds17

Activity records29

Assays5

Activity compounds and values

Activity records

29 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	10	nM	-	—	-	-	NCI-H1155	PGDB_A008958	PGDB_C005368	PGDB_AS001656	View
% Degradation	-	=	3.41	%	Concentration context: 100 nM	6 h	GSPT1	-	NCI-H1155	PGDB_A008992	PGDB_C005363	PGDB_AS001010	View
% Degradation	-	=	30.46	%	Concentration context: 10 nM	6 h	GSPT1	-	NCI-H1155	PGDB_A011864	PGDB_C005363	PGDB_AS000061	View
% Degradation	-	=	66.13	%	Concentration context: 10 nM	6 h	GSPT1	-	NCI-H1155	PGDB_A013042	PGDB_C005361	PGDB_AS000061	View
IC50	-	=	7	nM	-	—	-	-	NCI-H1155	PGDB_A015701	PGDB_C005364	PGDB_AS001656	View
% Degradation	-	=	4.06	%	Concentration context: 100 nM	6 h	GSPT1	-	NCI-H1155	PGDB_A017380	PGDB_C005361	PGDB_AS001010	View
IC50	-	=	25	nM	-	—	CRBN	CRBN	NCI-H1155	PGDB_A018808	PGDB_C001479	PGDB_AS001968	View
IC50	-	=	9	nM	-	—	-	-	NCI-H1155	PGDB_A020616	PGDB_C005365	PGDB_AS001656	View
IC50	-	=	21.5	nM	-	—	-	-	NCI-H1155	PGDB_A023816	PGDB_C001477	PGDB_AS001656	View
IC50	-	=	11	nM	-	—	-	-	NCI-H1155	PGDB_A025268	PGDB_C005367	PGDB_AS001656	View
IC50	-	=	57	nM	-	—	CRBN	CRBN	NCI-H1155	PGDB_A027361	PGDB_C000378	PGDB_AS001968	View
IC50	-	=	5	nM	-	—	-	-	NCI-H1155	PGDB_A028516	PGDB_C005361	PGDB_AS001656	View
IC50	-	=	239	nM	-	—	CRBN	CRBN	-	PGDB_A030392	PGDB_C005368	PGDB_AS000407	View
IC50	-	=	141	nM	-	—	CRBN	CRBN	NCI-H1155	PGDB_A033648	PGDB_C021942	PGDB_AS001968	View
IC50	-	=	23.5	nM	-	—	-	-	NCI-H1155	PGDB_A036954	PGDB_C001454	PGDB_AS001656	View
IC50	-	=	31.1	nM	-	—	CRBN	CRBN	NCI-H1155	PGDB_A038008	PGDB_C005371	PGDB_AS001968	View
% Degradation	-	=	25.46	%	Concentration context: 100 nM	6 h	GSPT1	-	NCI-H1155	PGDB_A038095	PGDB_C001479	PGDB_AS001010	View
IC50	-	=	83	nM	-	—	CRBN	CRBN	-	PGDB_A039175	PGDB_C005360	PGDB_AS000407	View
IC50	-	=	1.4	nM	-	—	-	-	NCI-H1155	PGDB_A040227	PGDB_C005360	PGDB_AS001656	View
IC50	-	=	59	nM	-	—	CRBN	CRBN	-	PGDB_A040950	PGDB_C005364	PGDB_AS000407	View

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