Activity record

PGDB_A027960

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

Emax = 9.6 %

TargetBRAF
Cell lineA375.10
Concentration10 uM
Time24 h
Assay / Readoutluminescence / Emax
Assay IDPGDB_AS001074
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005766
Compound IDPGDB_C005766
CompoundExample 114
Source record IDPGDB_C005766
InChIKeyMGCDKMSLLSQDTB-BHVANESWSA-N

Assay context

Assay IDPGDB_AS001074
Assay family% Degradation
Assay systemcell_based
ReadoutEmax
Technologyluminescence
Concentration10 uM
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 114

Example 114 enlarged structureExample 114 location on patent page 543
Activity table
Page 229 · table start
Page 230 · table end