Activity record

PGDB_A030662

Assay: % DegradationTarget: BRAFQC: ambiguous
Activity overview

DC50 = 16.51 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001629
PatentAU2022290851A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005782
Compound IDPGDB_C005782
CompoundExample 130
Source record IDPGDB_C005782
InChIKeyLUYDIEQAFJAINV-LHEWISCISA-N

Assay context

Assay IDPGDB_AS001629
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 130

Example 130 enlarged structureExample 130 location on patent page 554
Activity table
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