Activity record

PGDB_A034400

Assay: % DegradationTarget: IKZF1QC: standardized
Activity overview

DC50 = 0.11 nM

TargetIKZF1
E3 ligaseCRBN
Cell lineHT-1080
Time20 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001276
PatentWO2023025136A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009991
Compound IDPGDB_C009991
Compound化合物 4-A
Source record IDPGDB_C009991
InChIKeyLRFAFSWZAGPRMA-IRPSRAIASA-N

Assay context

Assay IDPGDB_AS001276
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time20 h
TargetIKZF1
E3CRBN
Cell lineHT-1080
OrganismHomo sapiens

Source evidence

Patent IDWO2023025136A1
Compound location

化合物 4-A

化合物 4-A enlarged structure化合物 4-A location on patent page 64
Activity table
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