Activity record

PGDB_A040799

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

Emax = 22.3 %

TargetBRAF
Cell lineA375.10
Concentration10 uM
Time24 h
Assay / Readoutluminescence / Emax
Assay IDPGDB_AS000362
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005828
Compound IDPGDB_C005828
CompoundExample 177
Source record IDPGDB_C005828
InChIKeyWLKUYWUPFQWNPZ-PQHLKRTFSA-N

Assay context

Assay IDPGDB_AS000362
Assay family% Degradation
Assay systemcell_based
ReadoutEmax
Technologyluminescence
Concentration10 uM
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 177

Example 177 enlarged structureExample 177 location on patent page 656
Activity table
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