Activity record

PGDB_A042902

Assay: % DegradationTarget: BRAFQC: ambiguous
Activity overview

DC50 = 12.93 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001629
PatentAU2022290851A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005759
Compound IDPGDB_C005759
CompoundExample 107
Source record IDPGDB_C005759
InChIKeyAVMZKTISAAMUBV-KDXMTYKHSA-N

Assay context

Assay IDPGDB_AS001629
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 107

Example 107 enlarged structureExample 107 location on patent page 536
Activity table
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