Activity record

PGDB_A042909

Assay: % DegradationTarget: GSPT1QC: ambiguous
Activity overview

degradation = 45 %

TargetGSPT1
Cell lineHL-60
Concentration0.1 uM
Time2 h
Assay / Readout% Degradation
Assay IDPGDB_AS000569
PatentWO2024073871A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C002875
Compound IDPGDB_C002875
CompoundB;B;B;B;B
Source record IDPGDB_C002875
InChIKeyBUPUIXDNVLUSRO-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000569
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
Concentration0.1 uM
Treatment time2 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHL-60

Source evidence

Patent IDWO2024073871A1
Compound location

B;B;B;B;B

B;B;B;B;B enlarged structureB;B;B;B;B location on patent page 48
Activity table
Page 93 · table start
Page 94 · table end