PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024073871A1

AssigneeBaifang Cayman

TitleGSPT1 degrading agents, compositions comprising the same, and methods of use thereof

Family ID90607478

Family members8

Filing year2023

Publication date2025-07-08

JurisdictionWO

Compounds28

Activity records67

Assays3

Activity compounds and values

Activity records

67 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	40	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A009692	PGDB_C002859	PGDB_AS000569	View
IC50	-	=	9.2	nM	-	—	GSPT1	-	HL-60	PGDB_A010092	PGDB_C002877	PGDB_AS000219	View
% Degradation	-	=	0	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A012950	PGDB_C002869	PGDB_AS000569	View
% Degradation	-	=	30	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A017711	PGDB_C002852	PGDB_AS000569	View
IC50	-	=	23	nM	-	—	GSPT1	-	HL-60	PGDB_A017879	PGDB_C002876	PGDB_AS000219	View
% Degradation	-	=	0	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A020268	PGDB_C002853	PGDB_AS001173	View
% Degradation	-	=	95	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A022297	PGDB_C002877	PGDB_AS001173	View
% Degradation	-	=	0	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A022945	PGDB_C002851	PGDB_AS001173	View
% Degradation	-	=	63	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A023659	PGDB_C002857	PGDB_AS001173	View
% Degradation	-	=	29	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A023672	PGDB_C002871	PGDB_AS001173	View
% Degradation	-	=	32	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A023676	PGDB_C002865	PGDB_AS001173	View
% Degradation	-	=	33	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A023723	PGDB_C002872	PGDB_AS000569	View
% Degradation	-	=	40	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A023810	PGDB_C002870	PGDB_AS001173	View
IC50	-	=	290	nM	-	—	GSPT1	-	HL-60	PGDB_A023978	PGDB_C002864	PGDB_AS000219	View
% Degradation	-	=	52	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A024451	PGDB_C002855	PGDB_AS001173	View
% Degradation	-	=	90	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A027064	PGDB_C002876	PGDB_AS001173	View
% Degradation	-	=	45	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A027843	PGDB_C002850	PGDB_AS000569	View
% Degradation	-	=	46	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A029710	PGDB_C002855	PGDB_AS000569	View
% Degradation	-	=	26	%	0.1 uM	2 h	GSPT1	-	HL-60	PGDB_A031282	PGDB_C002865	PGDB_AS000569	View
% Degradation	-	=	15	%	1 uM	2 h	GSPT1	-	HL-60	PGDB_A031542	PGDB_C002858	PGDB_AS001173	View

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