Activity record

PGDB_A043485

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 3.24 nM

TargetGSPT1
Cell lineHEK293
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS001853
PatentCN118852145A
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C001471
Compound IDPGDB_C001471
Compound实施例23
Source record IDPGDB_C001471
InChIKeyXMJNTKNLXDVCPP-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001853
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHEK293

Source evidence

Patent IDCN118852145A
Compound location

实施例23

实施例23 enlarged structure实施例23 location on patent page 58
Activity table
Page 93 · table single