PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN118852145A

AssigneeNanjing Sanhome Pharmaceutical

TitleGSPT1 degraders and their applications

Family ID93180166

Family members1

Filing year2024

Publication date2024-10-29

JurisdictionCN

Compounds31

Activity records64

Assays4

Activity compounds and values

Activity records

64 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	23.53	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A007000	PGDB_C001454	PGDB_AS001039	View
IC50	-	=	23.1	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A007688	PGDB_C001466	PGDB_AS001039	View
IC50	-	=	21.8	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A007709	PGDB_C001469	PGDB_AS001039	View
IC50	-	=	316.86	nM	-	—	CRBN	CRBN	-	PGDB_A008335	PGDB_C001475	PGDB_AS000570	View
IC50	-	=	25.4	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A009346	PGDB_C001476	PGDB_AS001039	View
IC50	-	=	333.25	nM	-	—	CRBN	CRBN	-	PGDB_A012014	PGDB_C001468	PGDB_AS000570	View
IC50	-	=	11.9	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A012720	PGDB_C001467	PGDB_AS001039	View
IC50	-	=	586.2	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A012936	PGDB_C001473	PGDB_AS001039	View
IC50	-	=	25.4	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A015479	PGDB_C001465	PGDB_AS001039	View
Dmax	-	=	93.1	%	Concentration series: 1 uM	24 h	GSPT1	-	HEK293	PGDB_A016560	PGDB_C001468	PGDB_AS002339	View
IC50	-	=	322.59	nM	-	—	CRBN	CRBN	-	PGDB_A017444	PGDB_C001470	PGDB_AS000570	View
IC50	-	=	756.73	nM	-	—	CRBN	CRBN	-	PGDB_A017562	PGDB_C001484	PGDB_AS000570	View
IC50	-	=	119.97	nM	-	—	CRBN	CRBN	-	PGDB_A018386	PGDB_C001471	PGDB_AS000570	View
IC50	-	=	20.28	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A019181	PGDB_C001461	PGDB_AS001039	View
IC50	-	=	5.7	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A019638	PGDB_C001468	PGDB_AS001039	View
IC50	-	=	9.23	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A020741	PGDB_C001455	PGDB_AS001039	View
Dmax	-	=	93.8	%	Concentration series: 1 uM	24 h	GSPT1	-	HEK293	PGDB_A021184	PGDB_C001465	PGDB_AS002339	View
Dmax	-	=	93.24	%	Concentration series: 1 uM	24 h	GSPT1	-	HEK293	PGDB_A022137	PGDB_C001466	PGDB_AS002339	View
IC50	-	=	72.7	nM	-	—	CRBN	CRBN	-	PGDB_A023974	PGDB_C001456	PGDB_AS000570	View
Dmax	-	=	93.56	%	Concentration series: 1 uM	24 h	GSPT1	-	HEK293	PGDB_A024704	PGDB_C001470	PGDB_AS002339	View

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