Activity record

PGDB_A055831

Assay: viabilityTarget: IKZF3QC: standardized
Activity overview

inhibition = 50-60 %

TargetIKZF3
Cell lineA375
Concentration500 nM
Time96 h
Assay / Readout% Inhibition / viability
Assay IDPGDB_AS000568
PatentWO2025162225A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C024202
Compound IDPGDB_C024202
CompoundGT-10081
Source record IDPGDB_C024202
InChIKeyNHPDNGBFQUDHED-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000568
Assay familyviability
Assay systemcell_based
Readout% Inhibition
Concentration500 nM
Treatment time96 h
Detection target% Cell viability
TargetIKZF3
E3Not specified
Cell lineA375
OrganismHomo sapiens

Source evidence

Patent IDWO2025162225A1
Compound location

GT-10081

GT-10081 enlarged structureGT-10081 location on patent page 31
Activity table
Page 157 · table single