Activity record

PGDB_A070716

Assay: % DegradationTarget: IKZF3QC: ambiguous
Activity overview

DC50 = 0.036 nM

TargetIKZF3
Cell lineNCI-H929
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000521
PatentCA3286762A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025617
Compound IDPGDB_C025617
CompoundExample 23
Source record IDPGDB_C006130
InChIKeyDMUCIXLYLXFAGV-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000521
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDCA3286762A1
Compound location

Example 23

Example 23 enlarged structureExample 23 location on patent page 74
Activity table
Page 102 · table single