Activity record

PGDB_A074731

Assay: % DegradationQC: standardized
Activity overview

DC50 = 8.86 nM

Cell lineNCI-H929
Time24 h
Assay / ReadoutWestern_blot / DC50
Assay IDPGDB_AS001024
PatentEP4685141A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025615
Compound IDPGDB_C025615
Compound实施例 21
Source record IDPGDB_C025615
InChIKeyMDWDRPAHWBVXTM-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001024
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
TechnologyWestern_blot
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDEP4685141A1
Compound location

实施例 21

实施例 21 enlarged structure实施例 21 location on patent page 49
Activity table
Page 67 · table start
Page 68 · table end