Activity record

PGDB_A077081

Assay: % DegradationQC: standardized
Activity overview

Emax > 60 %

Cell line293T.114
TimeDC50 > 10000 nM | Emax < 45%
Assay / Readoutluminescence / Emax
Assay IDPGDB_AS001060
PatentWO2022081927A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C016637
Compound IDPGDB_C016637
Compound66.0
Source record IDPGDB_C026767
InChIKeyPLOOUBMODVGWTK-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001060
Assay family% Degradation
Assay systemcell_based
ReadoutEmax
Technologyluminescence
Treatment timeDC50 > 10000 nM | Emax < 45%
TargetGSPT1
E3Not specified
Cell line293T.114
OrganismHomo sapiens

Source evidence

Patent IDWO2022081927A1
Compound location

66.0

66.0 enlarged structure66.0 location on patent page 540
Activity table
Page 540 · table start
Page 541 · table end