PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

50 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetGSPT1

E3Not specified

Cell lineKG-1

TechnologyWestern_blot

Detection targetprotein_degradation

Activity compounds and values

Activity records

50 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A007816	PGDB_C003259	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A008478	PGDB_C003232	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A011304	PGDB_C003263	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A011421	PGDB_C003239	PGDB_AS000482	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A011801	PGDB_C003252	PGDB_AS000482	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A012748	PGDB_C003241	PGDB_AS000482	View
% Degradation	-	<	25	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A015048	PGDB_C003228	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A018312	PGDB_C003262	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A020984	PGDB_C003254	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A023565	PGDB_C003248	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A024214	PGDB_C003253	PGDB_AS000482	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A024383	PGDB_C003250	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A025791	PGDB_C003238	PGDB_AS000482	View
% Degradation	-	<	25	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A026188	PGDB_C003267	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A028072	PGDB_C003236	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A028816	PGDB_C003249	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A030696	PGDB_C003246	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A032099	PGDB_C003231	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A033474	PGDB_C003266	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024222918A1	PGDB_A034997	PGDB_C003220	PGDB_AS000482	View

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