PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024222918A1

AssigneeChina Pharmaceutical University, Suzhou Yasheng Pharmaceutical

TitleBenzo-six-membered heterocyclic GSPT protein degradation agent and application thereof

Family ID92237566

Family members3

Filing year2024

Publication date2024-08-16

JurisdictionWO

Compounds50

Activity records124

Assays5

Activity compounds and values

Activity records

124 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	1-10	nM	-	—	GSPT1	-	KG-1	PGDB_A007277	PGDB_C003233	PGDB_AS002114	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A007816	PGDB_C003259	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A008478	PGDB_C003232	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A011304	PGDB_C003263	PGDB_AS000482	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A011421	PGDB_C003239	PGDB_AS000482	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A011435	PGDB_C003222	PGDB_AS002114	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	MOLM-13	PGDB_A011552	PGDB_C003266	PGDB_AS000118	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A011801	PGDB_C003252	PGDB_AS000482	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A012263	PGDB_C003237	PGDB_AS002114	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A012748	PGDB_C003241	PGDB_AS000482	View
IC50	-	=	1-10	nM	-	—	GSPT1	-	KG-1	PGDB_A013037	PGDB_C003249	PGDB_AS002114	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	U937	PGDB_A014025	PGDB_C003221	PGDB_AS002362	View
% Degradation	-	<	25	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A015048	PGDB_C003228	PGDB_AS000482	View
IC50	-	=	1-10	nM	-	—	GSPT1	-	KG-1	PGDB_A015572	PGDB_C003236	PGDB_AS002114	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	MOLM-13	PGDB_A015809	PGDB_C003221	PGDB_AS000118	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	U937	PGDB_A016725	PGDB_C000059	PGDB_AS002362	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A018312	PGDB_C003262	PGDB_AS000482	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A019084	PGDB_C003238	PGDB_AS002114	View
IC50	-	=	1-10	nM	-	—	GSPT1	-	KG-1	PGDB_A019248	PGDB_C003223	PGDB_AS002114	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A020984	PGDB_C003254	PGDB_AS000482	View

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