PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

14 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetVHL

E3Not specified

Cell lineSH-SY5Y

TechnologyWestern_blot

Detection targetprotein_degradation

Activity compounds and values

14 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	=	39	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A011154	PGDB_C006929	PGDB_AS001892	View
% Degradation	-	=	28	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A012032	PGDB_C006937	PGDB_AS001892	View
% Degradation	-	=	40	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A021761	PGDB_C006933	PGDB_AS001892	View
% Degradation	-	=	80	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A022677	PGDB_C006925	PGDB_AS001892	View
% Degradation	-	=	82	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A024284	PGDB_C006928	PGDB_AS001892	View
% Degradation	-	=	54	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A030754	PGDB_C006934	PGDB_AS001892	View
% Degradation	-	=	56	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A036890	PGDB_C006931	PGDB_AS001892	View
% Degradation	-	=	32	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A045639	PGDB_C006935	PGDB_AS001892	View
% Degradation	-	=	68	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A047248	PGDB_C006924	PGDB_AS001892	View
% Degradation	-	=	32	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A052437	PGDB_C006932	PGDB_AS001892	View
% Degradation	-	=	51	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A064508	PGDB_C006926	PGDB_AS001892	View
% Degradation	-	=	66	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A065733	PGDB_C006936	PGDB_AS001892	View
% Degradation	-	=	67	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A065832	PGDB_C006927	PGDB_AS001892	View
% Degradation	-	=	63	%	1 uM	24 h	VHL	-	SH-SY5Y	CN119613482A	PGDB_A076970	PGDB_C006930	PGDB_AS001892	View

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