PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN119613482A

AssigneeChina Pharmaceutical University

TitleCompound with terminal amino structure, preparation method, pharmaceutical composition and application thereof

Family ID94890220

Family members1

Filing year2024

Publication date2025-03-14

JurisdictionCN

Compounds14

Activity records28

Assays2

Activity compounds and values

Activity records

28 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	39	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A011154	PGDB_C006929	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A011709	PGDB_C006936	PGDB_AS000103	View
% Degradation	-	=	28	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A012032	PGDB_C006937	PGDB_AS001892	View
% Degradation	-	=	40	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A021761	PGDB_C006933	PGDB_AS001892	View
% Degradation	-	=	80	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A022677	PGDB_C006925	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A023786	PGDB_C006934	PGDB_AS000103	View
% Degradation	-	=	82	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A024284	PGDB_C006928	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A029167	PGDB_C006928	PGDB_AS000103	View
% Degradation	-	=	54	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A030754	PGDB_C006934	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A035537	PGDB_C006937	PGDB_AS000103	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A035851	PGDB_C006931	PGDB_AS000103	View
% Degradation	-	=	56	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A036890	PGDB_C006931	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A038856	PGDB_C006930	PGDB_AS000103	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A041491	PGDB_C006924	PGDB_AS000103	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A044712	PGDB_C006935	PGDB_AS000103	View
% Degradation	-	=	32	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A045639	PGDB_C006935	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A046111	PGDB_C006932	PGDB_AS000103	View
% Degradation	-	=	68	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A047248	PGDB_C006924	PGDB_AS001892	View
Ki	-	<	300	nM	-	—	VHL	VHL	-	PGDB_A051045	PGDB_C006933	PGDB_AS000103	View
% Degradation	-	=	32	%	1 uM	24 h	VHL	-	SH-SY5Y	PGDB_A052437	PGDB_C006932	PGDB_AS001892	View

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