PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(-c4cnn(C(F)F)c4-c4ccccc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C003455

FormulaC23H18F2N4O3

Molecular weight436.418

InChIKeyYHZFEZYNSNKOIM-UHFFFAOYSA-N

Physicochemical properties

Exact mass436.1347

RDKit cLogP3.37

TPSA84.3

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic5 / 3

Fraction Csp30.22

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	-	-	-	-	-	EP4584259A1	PGDB_A010190	PGDB_C003455	PGDB_AS001586	View
DC50	-	<	25	nM	-	—	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A011500	PGDB_C003455	PGDB_AS001103	View
% Degradation	-	=	0-25	%	Concentration range: 10 uM	six hours	GSPT1	-	HEK293	EP4584259A1	PGDB_A013244	PGDB_C003455	PGDB_AS001220	View
EC50	-	<	100	nM	-	—	-	-	-	EP4584259A1	PGDB_A018422	PGDB_C003455	PGDB_AS002128	View
DC50	-	>=	25	nM	-	—	GSPT1	-	HEK293	EP4584259A1	PGDB_A020037	PGDB_C003455	PGDB_AS001862	View
DC50	-	<	25	nM	-	—	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A020902	PGDB_C003455	PGDB_AS001103	View
% Degradation	-	=	75-90	%	Concentration range: 10 uM	six hours	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A030975	PGDB_C003455	PGDB_AS000108	View
% Degradation	-	=	0-25	%	Concentration range: 10 uM	six hours	GSPT1	-	HEK293	EP4584259A1	PGDB_A043172	PGDB_C003455	PGDB_AS001220	View
% Degradation	-	=	75-90	%	Concentration range: 10 uM	six hours	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A062003	PGDB_C003455	PGDB_AS000108	View
DC50	-	<	25	nM	-	—	GSPT1	-	HEK293	EP4584259A1	PGDB_A062040	PGDB_C003455	PGDB_AS001862	View

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