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Compound
PGDB_C003946
6 activity records1 related patents
2D structure
Cn1nc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1-c1ccc(C(F)(F)F)cc1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | - | < | 100 | nM | - | — | - | - | - | EP4584259A1 | PGDB_A011218 | PGDB_C003946 | PGDB_AS002128 | View |
| % Degradation | - | = | 0-25 | % | Concentration range: 10 uM | six hours | GSPT1 | - | HEK293 | EP4584259A1 | PGDB_A011857 | PGDB_C003946 | PGDB_AS001220 | View |
| % Degradation | - | = | 25-75 | % | Concentration range: 10 uM | six hours | CSNK1A1 | - | HEK293 | EP4584259A1 | PGDB_A014317 | PGDB_C003946 | PGDB_AS000108 | View |
| DC50 | - | < | 25 | nM | - | — | CSNK1A1 | - | HEK293 | EP4584259A1 | PGDB_A056384 | PGDB_C003946 | PGDB_AS001103 | View |
| DC50 | - | >= | 25 | nM | - | — | GSPT1 | - | HEK293 | EP4584259A1 | PGDB_A058575 | PGDB_C003946 | PGDB_AS001862 | View |
| % Degradation | - | = | 50-75 | % | - | - | - | - | - | EP4584259A1 | PGDB_A076760 | PGDB_C003946 | PGDB_AS001586 | View |