PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cn1cc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1C1CCCCC1

Compound summary

Compound IDPGDB_C004059

FormulaC23H26N4O3

Molecular weight406.486

InChIKeyQOMJSYXVQKNTMS-UHFFFAOYSA-N

Physicochemical properties

Exact mass406.2005

RDKit cLogP2.9

TPSA84.3

HBD / HBA1 / 5

Rotatable bonds3

Heavy atoms30

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.48

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-25	%	Concentration range: 10 uM	six hours	GSPT1	-	HEK293	EP4584259A1	PGDB_A007892	PGDB_C004059	PGDB_AS001220	View
% Degradation	-	=	90-100	%	Concentration range: 10 uM	six hours	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A014992	PGDB_C004059	PGDB_AS000108	View
DC50	-	<	25	nM	-	—	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A026576	PGDB_C004059	PGDB_AS001103	View
EC50	-	<	100	nM	-	—	-	-	-	EP4584259A1	PGDB_A028845	PGDB_C004059	PGDB_AS002128	View
% Degradation	-	=	25-75	%	Concentration range: 10 uM	six hours	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A029823	PGDB_C004059	PGDB_AS000108	View
% Degradation	-	=	90-100	%	-	-	-	-	-	EP4584259A1	PGDB_A045581	PGDB_C004059	PGDB_AS001586	View
DC50	-	<	25	nM	-	—	GSPT1	-	HEK293	EP4584259A1	PGDB_A046519	PGDB_C004059	PGDB_AS001862	View
DC50	-	>=	25	nM	-	—	CSNK1A1	-	HEK293	EP4584259A1	PGDB_A054919	PGDB_C004059	PGDB_AS001103	View
DC50	-	<	25	nM	-	—	GSPT1	-	HEK293	EP4584259A1	PGDB_A071970	PGDB_C004059	PGDB_AS001862	View
% Degradation	-	=	0-25	%	Concentration range: 10 uM	six hours	GSPT1	-	HEK293	EP4584259A1	PGDB_A073477	PGDB_C004059	PGDB_AS001220	View

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