PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)(C)c1ccc(C(=O)C(=O)NCc2scc3c2CN(C2CCC(=O)NC2=O)C3=O)cc1

Compound summary

Compound IDPGDB_C004431

FormulaC24H25N3O5S

Molecular weight467.547

InChIKeyPFNNFEGXYVOGCW-UHFFFAOYSA-N

Physicochemical properties

Exact mass467.1515

RDKit cLogP2.31

TPSA112.7

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms33

Hetero atoms9

Rings / aromatic4 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	50-80	%	0.1 uM	-	GSPT1	-	-	US20200369679A1	PGDB_A013044	PGDB_C004431	PGDB_AS001685	View
% Degradation	-	>=	80	%	0.1 uM	-	IKZF1	-	-	US20200369679A1	PGDB_A020323	PGDB_C004431	PGDB_AS002410	View
% Inhibition	-	>=	80	%	0.1 uM	1 h	-	-	-	US20200369679A1	PGDB_A024630	PGDB_C004431	PGDB_AS001873	View
% Inhibition	-	>=	80	%	0.1 uM	24 h	-	-	-	US20200369679A1	PGDB_A039591	PGDB_C004431	PGDB_AS000875	View
% Inhibition	-	>=	80	%	1 uM	3 d	-	-	MOLM-13	US20200369679A1	PGDB_A041853	PGDB_C004431	PGDB_AS001386	View
% Inhibition	-	=	50-80	%	0.1 uM	1 h	-	-	-	US20200369679A1	PGDB_A044507	PGDB_C004431	PGDB_AS001927	View
% Degradation	-	=	50-80	%	0.1 uM	-	CSNK1A1	-	-	US20200369679A1	PGDB_A047916	PGDB_C004431	PGDB_AS001805	View

Rows per pagePage 1 of 1 · 7 recordsGo to page