PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CCS(=O)(=O)c1cc(C(=O)N(c2ccc(F)cc2C2CC2)c2ccc([N+](=O)[O-])c3nonc23)c(OC)cc1N

Compound summary

Compound IDPGDB_C007049

FormulaC25H22FN5O7S

Molecular weight555.544

InChIKeyKGRIPICRCPSHLC-UHFFFAOYSA-N

Physicochemical properties

Exact mass555.1224

RDKit cLogP4.51

TPSA171.8

HBD / HBA1 / 10

Rotatable bonds8

Heavy atoms39

Hetero atoms14

Rings / aromatic5 / 4

Fraction Csp30.24

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	74.88	%	7.5 uM	9 h	MYC	-	Daudi	CN120040371B	PGDB_A007457	PGDB_C007049	PGDB_AS000260	View
% Degradation	-	=	67.29	%	1.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A014489	PGDB_C007049	PGDB_AS000827	View
% Degradation	-	=	87.18	%	12 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A019535	PGDB_C007049	PGDB_AS001763	View
IC50	-	=	3.731	uM	-	—	MYC	-	Daudi	CN120040371B	PGDB_A024720	PGDB_C007049	PGDB_AS000270	View
% Degradation	-	=	77.82	%	3 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A026034	PGDB_C007049	PGDB_AS000007	View
% Degradation	-	=	7.29	%	0.75 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A030112	PGDB_C007049	PGDB_AS000011	View
IC50	-	=	0.718	uM	-	—	MYC	-	SJSA-1	CN120040371B	PGDB_A037653	PGDB_C007049	PGDB_AS000442	View
% Degradation	-	=	97.11	%	7.5 uM	24 h	MYC	-	Daudi	CN120040371B	PGDB_A042955	PGDB_C007049	PGDB_AS000814	View
IC50	-	=	4.621	uM	-	—	MYC	-	COLO 320DM	CN120040371B	PGDB_A046694	PGDB_C007049	PGDB_AS001884	View
% Degradation	-	=	60.14	%	7.5 uM	3 h	MYC	-	Daudi	CN120040371B	PGDB_A048479	PGDB_C007049	PGDB_AS001136	View
IC50	-	=	5.383	uM	-	—	MYC	-	A2780	CN120040371B	PGDB_A052225	PGDB_C007049	PGDB_AS001017	View
% Degradation	-	=	84.18	%	6 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A053875	PGDB_C007049	PGDB_AS002218	View
% Degradation	-	=	69.18	%	7.5 uM	6 h	MYC	-	Daudi	CN120040371B	PGDB_A059112	PGDB_C007049	PGDB_AS002408	View
% Degradation	-	=	82.14	%	7.5 uM	12 h	MYC	-	Daudi	CN120040371B	PGDB_A061449	PGDB_C007049	PGDB_AS000998	View
IC50	-	=	7.821	uM	-	—	MYC	-	MV-4-11	CN120040371B	PGDB_A077597	PGDB_C007049	PGDB_AS001813	View

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