PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(CC(C)(C)C)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O

Compound summary

Compound IDPGDB_C008576

FormulaC27H39N3O3

Molecular weight453.627

InChIKeyJSDZXZBAZXSVAG-PSKXBURFSA-N

Physicochemical properties

Exact mass453.2991

RDKit cLogP3.96

TPSA78.5

HBD / HBA2 / 4

Rotatable bonds6

Heavy atoms33

Hetero atoms6

Rings / aromatic4 / 1

Fraction Csp30.67

Formal charge0

Fragments1

Activity compounds and values

Activity records

13 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A008937	PGDB_C008576	PGDB_AS002086	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A014438	PGDB_C008576	PGDB_AS000211	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A025710	PGDB_C008576	PGDB_AS000211	View
EC50	-	=	0.002	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A029886	PGDB_C008576	PGDB_AS001535	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A038522	PGDB_C008576	PGDB_AS002086	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A047401	PGDB_C008576	PGDB_AS000211	View
EC50	-	=	0.003	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A048435	PGDB_C008576	PGDB_AS001535	View
EC50	-	=	0.002	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A048646	PGDB_C008576	PGDB_AS001535	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A058058	PGDB_C008576	PGDB_AS001524	View
EC50	-	=	0.003	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A064468	PGDB_C008576	PGDB_AS001524	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A065767	PGDB_C008576	PGDB_AS002581	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A071944	PGDB_C008576	PGDB_AS002086	View
Dmax	-	=	101	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A072585	PGDB_C008576	PGDB_AS002581	View

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