PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberJP2026020265A

AssigneeGilead Sciences

TitleIKAROS ZINC FINGER FAMILY DEGRADING AGENTS AND USES THEREOF

Family ID85703921

Family members34

Filing year2025

Publication date2026-02-06

JurisdictionJP

Compounds289

Activity records1,610

Assays13

Activity compounds and values

Activity records

1,610 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	=	0.002	uM	-	—	IKZF2	-	HEK293	PGDB_A007003	PGDB_C008612	PGDB_AS001535	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	PGDB_A007008	PGDB_C008691	PGDB_AS001573	View
EC50	-	=	0.114	uM	-	—	IKZF1	-	HEK293	PGDB_A007014	PGDB_C008689	PGDB_AS002086	View
EC50	-	=	0.094	uM	-	—	SALL4	-	HEK293	PGDB_A007130	PGDB_C008697	PGDB_AS001573	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	HEK293	PGDB_A007171	PGDB_C008575	PGDB_AS001535	View
EC50	-	=	0.261	uM	-	—	IKZF1	-	HEK293	PGDB_A007279	PGDB_C008416	PGDB_AS002086	View
Dmax	-	=	71	%	-	24 h	IKZF2	-	HEK293	PGDB_A007329	PGDB_C008701	PGDB_AS000211	View
EC50	-	=	0.072	uM	-	—	IKZF1	-	HEK293	PGDB_A007349	PGDB_C008536	PGDB_AS002086	View
Dmax	-	=	64	%	-	24 h	IKZF2	-	HEK293	PGDB_A007515	PGDB_C026739	PGDB_AS000211	View
Dmax	-	=	49	%	-	24 h	IKZF2	-	HEK293	PGDB_A007562	PGDB_C008402	PGDB_AS000211	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	HEK293	PGDB_A007620	PGDB_C008551	PGDB_AS001535	View
EC50	-	=	0.02	uM	-	—	IKZF2	-	HEK293	PGDB_A007628	PGDB_C008566	PGDB_AS001535	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	HEK293	PGDB_A007629	PGDB_C008578	PGDB_AS000211	View
EC50	-	=	0.023	uM	-	—	IKZF2	-	HEK293	PGDB_A007631	PGDB_C008542	PGDB_AS001535	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	PGDB_A007740	PGDB_C008544	PGDB_AS001573	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	-	PGDB_A007785	PGDB_C008550	PGDB_AS002581	View
EC50	-	=	0.03	uM	-	—	IKZF1	-	HEK293	PGDB_A007791	PGDB_C008580	PGDB_AS002086	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	PGDB_A007886	PGDB_C008560	PGDB_AS000211	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	HEK293	PGDB_A008000	PGDB_C008586	PGDB_AS000211	View
EC50	-	=	0.019	uM	-	—	IKZF2	-	HEK293	PGDB_A008056	PGDB_C008682	PGDB_AS001535	View

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