PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCC1

Compound summary

Compound IDPGDB_C008587

FormulaC26H35N3O3

Molecular weight437.584

InChIKeyCQPBQIZIXUHWHV-NOQOPHEDSA-N

Physicochemical properties

Exact mass437.2678

RDKit cLogP3.33

TPSA78.5

HBD / HBA2 / 4

Rotatable bonds6

Heavy atoms32

Hetero atoms6

Rings / aromatic5 / 1

Fraction Csp30.65

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	0.004	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A008817	PGDB_C008587	PGDB_AS001524	View
EC50	-	=	0.01	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A015072	PGDB_C008587	PGDB_AS001524	View
EC50	-	=	0.006	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A017299	PGDB_C008587	PGDB_AS001535	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A020740	PGDB_C008587	PGDB_AS002581	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A024260	PGDB_C008587	PGDB_AS001524	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A027410	PGDB_C008587	PGDB_AS002581	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A029412	PGDB_C008587	PGDB_AS002581	View
EC50	-	=	0.002	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A036106	PGDB_C008587	PGDB_AS001535	View
EC50	-	=	0.626	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A042608	PGDB_C008587	PGDB_AS002086	View
Dmax	-	=	95	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A055475	PGDB_C008587	PGDB_AS000211	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A060850	PGDB_C008587	PGDB_AS002086	View
Dmax	-	=	34	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A069564	PGDB_C008587	PGDB_AS000216	View
Dmax	-	=	95	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A074544	PGDB_C008587	PGDB_AS000211	View
% Degradation	-	=	0.47	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A074997	PGDB_C008587	PGDB_AS000906	View

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