PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NC4CCC(F)(F)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008614

FormulaC26H32F3N3O3

Molecular weight491.554

InChIKeySHCAYDSOZOJMAO-GZOQVGHDSA-N

Physicochemical properties

Exact mass491.2396

RDKit cLogP3.86

TPSA78.5

HBD / HBA2 / 4

Rotatable bonds5

Heavy atoms35

Hetero atoms9

Rings / aromatic5 / 1

Fraction Csp30.65

Formal charge0

Fragments1

Activity compounds and values

Activity records

13 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A010774	PGDB_C008614	PGDB_AS002086	View
EC50	-	=	0.05	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A021157	PGDB_C008614	PGDB_AS002391	View
EC50	-	=	0.028	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A023053	PGDB_C008614	PGDB_AS002086	View
EC50	-	=	0.001	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A024703	PGDB_C008614	PGDB_AS001524	View
EC50	-	=	0.001	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A025940	PGDB_C008614	PGDB_AS001535	View
EC50	-	=	0.2	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A028896	PGDB_C008614	PGDB_AS001603	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A031305	PGDB_C008614	PGDB_AS000211	View
Dmax	-	=	97	%	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A038877	PGDB_C008614	PGDB_AS002429	View
Dmax	-	=	93	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A040846	PGDB_C008614	PGDB_AS002581	View
Dmax	-	=	84	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A043967	PGDB_C008614	PGDB_AS000211	View
Dmax	-	=	68	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A057506	PGDB_C008614	PGDB_AS000216	View
EC50	-	=	0.033	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A066770	PGDB_C008614	PGDB_AS001535	View
Fold change	DMSO control	=	2.6	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A070553	PGDB_C008614	PGDB_AS002326	View

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