PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4N[C@H]4CC[C@@H](F)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008634

FormulaC25H31F2N3O4

Molecular weight475.536

InChIKeyXMGQJVIOLKWXRR-HGSFDSRTSA-N

Physicochemical properties

Exact mass475.2283

RDKit cLogP2.55

TPSA87.7

HBD / HBA2 / 5

Rotatable bonds5

Heavy atoms34

Hetero atoms9

Rings / aromatic5 / 1

Fraction Csp30.64

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	27	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A014034	PGDB_C008634	PGDB_AS000216	View
EC50	-	=	0.005	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A015193	PGDB_C008634	PGDB_AS001535	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A016057	PGDB_C008634	PGDB_AS001573	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A017349	PGDB_C008634	PGDB_AS001573	View
Dmax	-	=	98	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A033617	PGDB_C008634	PGDB_AS000211	View
Dmax	-	=	31	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A037450	PGDB_C008634	PGDB_AS000216	View
EC50	-	=	0.138	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A039933	PGDB_C008634	PGDB_AS002086	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A043960	PGDB_C008634	PGDB_AS000211	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A046250	PGDB_C008634	PGDB_AS002581	View
EC50	-	=	0.005	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A048186	PGDB_C008634	PGDB_AS001524	View
% Degradation	-	=	0.47	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A059810	PGDB_C008634	PGDB_AS000906	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A062919	PGDB_C008634	PGDB_AS001535	View
Dmax	-	=	90	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A065270	PGDB_C008634	PGDB_AS002581	View
EC50	-	=	0.006	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A066534	PGDB_C008634	PGDB_AS001524	View
EC50	-	=	0.632	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A069555	PGDB_C008634	PGDB_AS002086	View

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