PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCc5c(C(F)(F)F)n[nH]c5C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008689

FormulaC28H32F3N5O3

Molecular weight543.59

InChIKeyUNYUPACYOWGOFE-NSTAKLTISA-N

Physicochemical properties

Exact mass543.2457

RDKit cLogP3.44

TPSA107.2

HBD / HBA3 / 5

Rotatable bonds5

Heavy atoms39

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.57

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	0.114	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A007014	PGDB_C008689	PGDB_AS002086	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A008499	PGDB_C008689	PGDB_AS001573	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A010142	PGDB_C008689	PGDB_AS000211	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A011059	PGDB_C008689	PGDB_AS001535	View
EC50	-	=	0.048	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A018317	PGDB_C008689	PGDB_AS002086	View
Dmax	-	=	99	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A028870	PGDB_C008689	PGDB_AS000211	View
EC50	-	=	0.001	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A039380	PGDB_C008689	PGDB_AS001535	View
EC50	-	=	0.05	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A050151	PGDB_C008689	PGDB_AS002086	View
Dmax	-	=	65	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A052599	PGDB_C008689	PGDB_AS000216	View
Dmax	-	=	56	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A054127	PGDB_C008689	PGDB_AS000216	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A056358	PGDB_C008689	PGDB_AS001573	View
Dmax	-	=	39	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A064185	PGDB_C008689	PGDB_AS000216	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A064503	PGDB_C008689	PGDB_AS000211	View
EC50	-	=	0.011	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A068219	PGDB_C008689	PGDB_AS001535	View

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