PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NCC45CC(C4)C5)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008726

FormulaC26H32FN3O3

Molecular weight453.558

InChIKeySNLLZEHTYJZXAN-GJUFMYDOSA-N

Physicochemical properties

Exact mass453.2428

RDKit cLogP3.08

TPSA78.5

HBD / HBA2 / 4

Rotatable bonds6

Heavy atoms33

Hetero atoms7

Rings / aromatic7 / 1

Fraction Csp30.65

Formal charge0

Fragments1

Activity compounds and values

Activity records

53 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	96	%	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A008545	PGDB_C008726	PGDB_AS002429	View
EC50	-	=	0.055	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A008874	PGDB_C008726	PGDB_AS001535	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A009044	PGDB_C008726	PGDB_AS002086	View
EC50	-	=	0.081	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A009457	PGDB_C008726	PGDB_AS002086	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A010070	PGDB_C008726	PGDB_AS002086	View
Dmax	-	=	36	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A010517	PGDB_C008726	PGDB_AS000216	View
EC50	-	=	0.009	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A011828	PGDB_C008726	PGDB_AS001535	View
Fold change	DMSO control	=	2.5	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A013448	PGDB_C008726	PGDB_AS002326	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A015417	PGDB_C008726	PGDB_AS000211	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A015739	PGDB_C008726	PGDB_AS000211	View
EC50	-	=	3.4	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A016291	PGDB_C008726	PGDB_AS001603	View
EC50	-	=	0.002	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A016851	PGDB_C008726	PGDB_AS001535	View
EC50	-	=	0.003	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A016954	PGDB_C008726	PGDB_AS001535	View
EC50	-	=	0.004	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A017611	PGDB_C008726	PGDB_AS001535	View
EC50	-	=	0.017	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A019407	PGDB_C008726	PGDB_AS001535	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A022352	PGDB_C008726	PGDB_AS000211	View
EC50	-	=	0.163	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A022858	PGDB_C008726	PGDB_AS002086	View
Fold change	DMSO control	=	2.7	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A025189	PGDB_C008726	PGDB_AS002326	View
EC50	-	=	0.6	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A029395	PGDB_C008726	PGDB_AS001603	View
Dmax	-	=	96	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A029595	PGDB_C008726	PGDB_AS000211	View

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