PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)(C)CCN(CCC(C)(C)C)[C@H]1CCCC[C@@H]1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O

Compound summary

Compound IDPGDB_C008727

FormulaC32H48FN3O3

Molecular weight541.752

InChIKeySMEIIAAQYZSASJ-YUHGSZGMSA-N

Physicochemical properties

Exact mass541.368

RDKit cLogP5.86

TPSA69.7

HBD / HBA1 / 4

Rotatable bonds8

Heavy atoms39

Hetero atoms7

Rings / aromatic4 / 1

Fraction Csp30.72

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	90	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A009273	PGDB_C008727	PGDB_AS000211	View
Fold change	DMSO control	=	2.1	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A010858	PGDB_C008727	PGDB_AS002326	View
EC50	-	=	0.1	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A014455	PGDB_C008727	PGDB_AS002391	View
Dmax	-	=	29	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A021487	PGDB_C008727	PGDB_AS000216	View
EC50	-	=	1.4	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A027008	PGDB_C008727	PGDB_AS002391	View
Dmax	-	=	75	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A039188	PGDB_C008727	PGDB_AS000211	View
EC50	-	=	1.9	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A045117	PGDB_C008727	PGDB_AS001603	View
EC50	-	=	0.033	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A048595	PGDB_C008727	PGDB_AS001535	View
EC50	-	>	1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A049562	PGDB_C008727	PGDB_AS002086	View
Dmax	-	=	90	%	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A054635	PGDB_C008727	PGDB_AS002429	View
EC50	-	=	0.03	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A062788	PGDB_C008727	PGDB_AS001603	View
EC50	-	=	0.069	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A064348	PGDB_C008727	PGDB_AS001535	View
Dmax	-	=	90	%	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A065149	PGDB_C008727	PGDB_AS002429	View
Fold change	DMSO control	=	2	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A071638	PGDB_C008727	PGDB_AS002326	View
EC50	-	=	0.1	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A073609	PGDB_C008727	PGDB_AS002086	View

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